1. Preheat your oven to 375°F. This gives you just enough time to prepare everything else.
2. Cook the penne pasta according to the package instructions until al dente. Drain and set aside.
3. In a large skillet, heat olive oil over medium heat. Add the ground beef, breaking it apart as it cooks until browned and cooked through, about 6-8 minutes.
4. Stir in the marinara sauce, Italian seasoning, garlic powder, salt, and pepper. Let the sauce simmer for about 5 minutes, allowing the flavors to meld together.
5. Combine the cooked pasta with the beef and sauce mixture, ensuring everything is well coated.
6. Transfer the pasta and beef mixture to a large baking dish. Top with shredded mozzarella and cheddar cheeses, spreading evenly.
7. Bake in the preheated oven for 20 minutes, or until the cheese is bubbly and golden brown. My little tip: if you want a bit of a crispy top, switch to broil for the last 2 minutes, watching closely.
8. Remove from the oven and let it sit for a few minutes before serving. This helps the bake set a little, making it easier to serve.

From my kitchen to yours, this dish is all about bringing joy and warmth to your dining table, just like my mom did with her magical cooking.